Los Angeles - Your new friendly neighbourhood Spider-Man has spun himself a $65m opening weekend and $140m in his first six days at US theatres.
Overseas, Sony's The Amazing Spider-Man added $129.1m, raising its international total to $201.6m and worldwide haul to $341.2m since it began rolling out a week earlier in some foreign markets.
The movie started off as a smaller domestic moneymaker than the previous three Spidey films, but it laid to rest objections that it was too soon to relaunch the superhero franchise.
The new origin story for the Marvel Comics web-slinger comes just five years after Spider-Man 3, Tobey Maguire and director Sam Raimi's final movie in a series that shattered box-office records.
"This was never modeled or was never meant to be Spider-Man 4. This was always a relaunch with a new cast and different stories to tell, and quite frankly, it succeeded beyond our imaginations," said Rory Bruer, Sony's head of distribution.
The previous weekend's No 1 film, Universal's teddy-bear comedy Ted, fell to second place with $32.6m, raising its domestic total to $120.2m.
Among new releases, Oliver Stone's drug-war thriller Savages opened at No 4 with a solid $16.2m weekend, also for Universal. Paramount's concert film Katy Perry: Part of Me failed to pack in the pop star's fans, debuting at a distant No 8 with just $7.2m.
Going into wide release after two weekends in a handful of theaters, Woody Allen's ensemble romance To Rome with Love broke into the top 10 with $3.5m. The Sony Pictures Classics release lifted its domestic total to $5.3m.
The Amazing Spider-Man bumped up US receipts, with Hollywood pulling in an estimated $200m overall for the weekend, according to box-office tracker Hollywood.com. That's a 28.6% increase over the same weekend last year, when Transformers: Dark of the Moon led with $47.1m in its second weekend.
Leading up to the domestic debut of Amazing Spider-Man last Tuesday, Hollywood had expectations of a six-day total of around $120m for the film by the end of the Fourth of July holiday weekend. That proved a conservative projection, but studio executives genuinely were uncertain how well the film might do so close on the heels of the previous Spider-Man series.
"To expect the kind of numbers the first Spider-Man did or the second or third would have been kind of reaching," said Hollywood.com analyst Paul Dergarabedian. "For a reboot that people definitely were on the fence about initially, I think this is a really strong performance."
Raimi and Maguire's Spider-Man was the first movie to top $100m in a single weekend, opening with $114.8m in 2002. Spider-Man 3 set a new weekend record with its $151.1m debut, which has since been surpassed by such films as 2008's The Dark Knight, last year's Harry Potter finale and the current record-holder, The Avengers, with $207.4m in May.
While it took more than a weekend for The Amazing Spider-Man to put up numbers comparable to the earlier Spidey flicks, the film has good reviews and fan reaction for the new cast and crew to build on in subsequent instalments.
"With a film that is a relaunch like this, with a new cast, a new director, there are a lot of pieces. You have to prove yourself, just like Batman Begins had to prove itself and went on to have such incredible success with Dark Knight," Sony's Bruer said.
Katy Perry bombs
"This is a new trilogy and a new era of Spider-Man. We certainly have very much in our minds where it's going to go with the story arc. It's just going to be an incredible several years with this relaunch. We have a lot of great stories to tell."
Andrew Garfield stars as teen orphan Peter Parker, who becomes a vengeful vigilante and later an urban protector after the bite of a mutant spider gives him super strength, agility and senses. Marc Webb ((500) Days of Summer) directed the film, which co-stars Emma Stone, Rhys Ifans, Sally Field and Martin Sheen.
Amazing Spider-Man had a price advantage over its predecessors. This was the first 3D Spidey movie, earning 44% of its domestic revenues from 3D screenings, which cost a few dollars more than 2D shows.
The film is the centrepiece of a huge superhero summer that started with The Avengers and continues with the 20 July debut of The Dark Knight Rises, the finale of Christopher Nolan and Christian Bale's Batman trilogy.
Director Stone's Savages chronicles a bloody war between California marijuana growers and a merciless Mexican cartel trying to muscle into their business. The ensemble cast includes Salma Hayek, John Travolta, Benicio Del Toro, Blake Lively, Taylor Kitsch and Aaron Johnson.
Katy Perry's Part of Me raised its domestic total to $10.3m since opening Thursday. Her mix of 3D stage show and backstage documentary was a bust compared to such concert hits as 2008's Hannah Montana & Miley Cyrus: Best of Both Worlds Concert, which opened with $31.1m, and last year's Justin Bieber: Never Say Never, which premiered with $29.5m.
Part of Me did not even live up to the 2009 dud Jonas Brothers: The 3D Concert Experience, with a $12.5m debut.