Yerevan - France striker Karim Benzema and defender Eliaquim Mangala are doubtful for the friendly against Armenia on Tuesday, while goalkeeper Hugo Lloris is ruled out, coach Didier Deschamps revealed on Monday.
Marseille's Steve Mandanda looks set to continue in goal with captain and first-choice 'keeper Lloris still recovering from a groin problem.
"For Hugo, he is a a lot better but he won't play tomorrow (Tuesday)," said Deschamps, about the Tottenham 'keeper, who could also hand a first international appearance to Rennes custodian Benoit Costil.
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Real Madrid marksman Benzema, who scored the opener during Saturday's 2-1 victory over Portugal, may be replaced by in-form Marseille striker Andre-Pierre Gignac who is the early top scorer in Ligue 1 with nine goals in nine matches.
"Karim took a knock on his right foot and Eliaquim felt a problem in his thigh, so they didn't train on Monday afternoon and a decision will be made in the evening on whether they will play," said the 45-year-old Deschamps, who opened the door for a starting spot for Gignac.
"It is not difficult to imagine but in any case he will get more minutes than during his last match against Portugal on Saturday," added Deschamps who brought on Gignac in injury time at the Stade de France.
Two-time European champions France (1984 and 2000) qualify automatically for Euro 2016 as the host nation.