London - Chelsea could have to begin the defense of its Premier League title without striker Diego Costa when the champions host Swansea at Stamford Bridge on Saturday on the opening weekend of the new season.
The Spain striker, who propelled Chelsea to the domestic title with 20 goals in 2014-15, missed his side's 1-0 loss to Arsenal in the Community Shield last weekend with a hamstring problem. It's the same type of injury that restricted his appearances throughout the last campaign and Jose Mourinho is unlikely to risk Costa's health early. That means new signing Radamel Falcao could spearhead Chelsea's attack for the opening encounter.
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Falcao's arrival at Chelsea is an intriguing one, the Colombia international was one of the most prolific marksmen in the game until his clinical form deserted him last season during a loan spell at Manchester United from Monaco.
He managed only four goals in 29 appearances in an underwhelming year at Old Trafford.
But Mourinho has taken a chance on the forward, again on loan, hoping to help Falcao return to the form that saw him score 68 times in 86 appearances for Atletico Madrid from 2011-13.
Here are some other things to know ahead of the first round of Premier League fixtures this weekend:
First the worst for United?
Manchester United began last season with the early Saturday kick-off against Swansea and lost 2-1 at Old Trafford in Louis van Gaal's first game in charge.
The Dutchman will be hoping it is not an omen, as his team again takes part in the Premier League curtain raiser on Saturday, this time hosting Tottenham.
Van Gaal could hand debuts to Memphis Depay, Bastian Schweinsteiger, Morgan Schneiderlin and Matteo Darmian and still has David De Gea in his ranks, despite regular reports Real Madrid is lining up a move for the goalkeeper.
De Gea will have to keep Tottenham's Harry Kane at bay, as the striker looks to build upon his breakthrough season last year where he scored 31 goals in all competitions.
Rodgers back at the Britannia
Liverpool returns to Stoke on Sunday, the scene of a humiliating 6-1 mauling on the final day of last season.
A beleaguered Brendan Rodgers accepted after the game that "if the owners want me to go, I will go."
But he remains as Liverpool manager and leads a new-look side back to Stoke, looking to banish the memories of the defeat in May.
Christian Benteke bolsters Liverpool's attack after a $50.7-million switch from Aston Villa. Behind him, Phillippe Coutinho could be partnered by his Brazil compatriot Roberto Firmino, who joined Liverpool in a reported $45.8-million transfer from Hoffenheim.
Central midfielder James Milner, a free transfer from Manchester City, appears set to fill the void left by former captain Steven Gerrard, who left after 17 years for the Los Angeles Galaxy. Jordan Henderson takes over the armband.
Rodgers has spent big in the offseason and the team must show significant improvement early, or he will immediately be back under scrutiny.
Cech mate for Arsenal
Arsenal's season begins at home to West Ham and Arsene Wenger can be quietly optimistic of his team's chances of mounting a title challenge.
The arrival of goalkeeper Petr Cech, from London rival Chelsea, strengthens a defense that has often lacked the assured nature of its rivals, such as Chelsea and Manchester City, who have regularly competed for domestic glory in recent years.
The 33-year-old Cech won four Premier League titles at Stamford Bridge and his presence is expected to add some sternness to Arsenal's backline.
Striker Alexis Sanchez will not feature against Slaven Bilic's West Ham. He is being rested after winning the Copa America with Chile in July.
Sterling set for City debut
Raheem Sterling can make his debut for Manchester City on Monday at West Bromwich Albion.
The winger became the most expensive English footballer ever when he signed for $76 million from Liverpool in July.
City finished second to Chelsea last year, surrendering its Premier League title by eight points.
Despite only being 20 years old, Sterling will be expected to repay some of his fee swiftly as Manuel Pellegrini's side attempt to overturn the gap this time around.