Barcelona - Real Madrid defender Pepe has a leg injury and is set to miss the opening match of their La Liga season against Sporting Gijon on Aug. 23, his club said on Friday.
Also read: De Gea pulled by Man U against Spurs after transfer rumour
The Portuguese centre back was forced off after just 16 minutes of a friendly against Bayern Munich on Wednesday, which Real lost 1-0.
"A muscle injury to his right leg has been diagnosed following tests," read a statement from Real.
According to Spanish media reports, he could be out of action for up to three weeks, which would rule him out of their match against newly-promoted Sporting.
Real are aiming to rebound under new coach Rafa Benitez after failing to secure a major trophy last season, which led to the sacking of former boss Carlo Ancelotti.
Benitez is also set to be without forward Karim Benzema, who has a thigh injury.