Nyon - Manchester United and Liverpool will face each other for the first time in European competition after being drawn together in the Europa League last 16.
The fixture means two tough games for teams which are both struggling in the English Premier League, where United is fifth and Liverpool eighth.
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The draw on Friday also means an all-Spanish matchup between Valencia and Athletic Bilbao, while reigning Europa League champion Sevilla meets Swiss team Basel.
Another high-profile fixture pits Premier League title challenger Tottenham against Bundesliga side Borussia Dortmund.