Cairo - EgyptAir Flight 804 heading from Paris to Cairo, Egypt, with 66 people on board, has disappeared from radar, CNN reported on Thursday.
According to BBC News, the Airbus A320 was flying at 11 300m when it went missing over the eastern Mediterranean.
An official said the plane lost contact with radar at 02:45 Cairo time (00:45 GMT).
EgyptAir said search and rescue teams had been deployed.
Last October, a Russian passenger plane flying from Sharm el-Sheikh crashed over the Sinai Peninsula, killing all 224 people on board.
Officials in Moscow later said the aircraft was brought down by an explosive device.